7/5/2023 0 Comments Relax relate release wikiIt also relaxes other pelvic ligaments in the lower reproductive tract. In pregnancy, relaxin mediates the hemodynamic changes that occur such as increased cardiac output and increased renal blood flow. Blood plasma levels of relaxin peak during the first trimester (8-12 weeks) at 1.2 ng/mL and subsequently drop following demise of the corpus luteum. During the first trimester of pregnancy, levels rise and additional relaxin is produced by the decidua. Relaxin may be involved in the vital process of decidualisation, working alongside steroid hormones to allow the endometrium to prepare for implantation. Relaxin levels rise to a peak within approximately 14 days of ovulation, and then decline in the absence of pregnancy, resulting in menstruation. In females, relaxin is produced mainly by the corpus luteum, in both pregnant and nonpregnant females. Relaxin is produced from its prohormone, "prorelaxin", by post-translational proteolytic cleavage of its signal peptide and C domain peptide. Structurally, relaxin is a heterodimer of two peptide chains of 24 and 29 amino acids linked by three disulfide bridges, and it appears related to insulin. In the male, it is produced in the prostate and is present in human semen. In the female, relaxin is produced by the corpus luteum of the ovary, the breast and, during pregnancy, also by the placenta, chorion, and decidua. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised. The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity relaxin-1 (RLN1), 2 (RLN2) and 3 ( RLN3), and the insulin-like (INSL) peptides, INS元, INSL4, INSL5 and INSL6. Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw. For the Miles Davis album, see Relaxin' with the Miles Davis Quintet.
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